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| Childhood cases (under 20 years of age) represent about 2% of all patients who develop chronic myelogenous leukemia. The frequency of the disease increases with age from about one in 1 million children in the first 10 years of life to one in 100,000 people at age 50, to one in 10,000 people at age 80 and above. This injury is not present at birth. Further studies established that two chromosomes, usually chromosome Nos. The detached portion of chromosome 9 sticks to the broken end of chromosome 22, and the detached portion of chromosome 22 sticks to the broken end of chromosome 9. This abnormal exchange of parts of chromosomes is called a translocation. The cause of the chromosomal breakage in virtually all CML patients is not known. Signs & Symptoms The onset of chronic myelogenous leukemia is associated with symptoms that usually develop gradually. Most patients feel a loss of well-being. Since the disease worsens over weeks or months, most patients would have symptoms develop soon after such a medical examination in any case. The white cell count invariably increases, often to very high levels. |
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